Abstract
Acute pancreatitis represents a spectrum of disease ranging from a mild, self-limited course to a rapidly progressive, severe illness. The mortality rate of severe acute pancreatitis exceeds 20%, and some patients diagnosed as mild to moderate acute pancreatitis at the onset of the disease may progress to a severe, life-threatening illness within 2–3 days. The Japanese (JPN) guidelines were designed to provide recommendations regarding the management of acute pancreatitis in patients having a diversity of clinical characteristics. This article sets forth the JPN guidelines for the surgical management of acute pancreatitis, excluding gallstone pancreatitis, by incorporating the latest evidence for the surgical management of severe pancreatitis in the Japanese-language version of the evidence-based Guidelines for the Management of Acute Pancreatitis published in 2003. Ten guidelines are proposed: (1) computed tomography-guided or ultrasound-guided fine-needle aspiration for bacteriology should be performed in patients suspected of having infected pancreatic necrosis; (2) infected pancreatic necrosis accompanied by signs of sepsis is an indication for surgical intervention; (3) patients with sterile pancreatic necrosis should be managed conservatively, and surgical intervention should be performed only in selected cases, such as those with persistent organ complications or severe clinical deterioration despite maximum intensive care; (4) early surgical intervention is not recommended for necrotizing pancreatitis; (5) necrosectomy is recommended as the surgical procedure for infected pancreatic necrosis; (6) simple drainage should be avoided after necrosectomy, and either continuous closed lavage or open drainage should be performed; (7) surgical or percutaneous drainage should be performed for pancreatic abscess; (8) pancreatic abscesses for which clinical findings are not improved by percutaneous drainage should be subjected to surgical drainage immediately; (9) pancreatic pseudocysts that produce symptoms and complications or the diameter of which increases should be drained percutaneously or endoscopically; and (10) pancreatic pseudocysts that do not tend to improve in response to percutaneous drainage or endoscopic drainage should be managed surgically.
Similar content being viewed by others
Clinical questions
-
CQ1.
Which procedure will best result in a definite diagnosis of infected pancreatic necrosis?
-
CQ2.
What is the indication for surgical intervention in necrotizing pancreatitis?
-
CQ3.
How should sterile pancreatic necrosis be managed?
-
CQ4.
What is the optimal timing for surgical intervention?
-
CQ5.
What is the optimal surgical procedure for infected pancreatic necrosis?
-
CQ6.
What is the optimal drainage procedure after necrosectomy?
-
CQ7.
How should pancreatic abscess be managed?
-
CQ8.
What is the indication for surgical drainage in pancreatic abscess?
-
CQ9.
What are the indications for drainage treatment in pancreatic pseudocysts?
-
CQ10.
What is the indication for surgical intervention in pancreatic pseudocysts?
Introduction
Research on the pathophysiology of acute pancreatitis has progressed dramatically during the past 20 years. As the number of randomized controlled studies (RCTs, mainly done in the United States and Europe) on the management of severe acute pancreatitis has increased, evidence-based management has come to be demanded. Several guidelines and recommendations for acute pancreatitis have been published in recent years,1–4 and three institutions in Japan — the Japanese Society for Abdominal Emergency Medicine, the Japan Pancreas Society, and the Research Group for Intractable Diseases and Refractory Pancreatic Diseases, which is sponsored by the Japanese Ministry of Health, Labour and Welfare — collaborated to publish the Japanese-language version of the evidence-based Guidelines for the Management of Acute Pancreatitis in 2003. This paper sets forth the JPN guidelines for the surgical management of acute pancreatitis, which incorporate the latest evidence for the surgical management of severe pancreatitis and are based on the Japaneselanguage version of the guidelines. The surgical management of gallstone pancreatitis is included in the JPN guidelines for the treatment of gallstone-associated acute pancreatitis.
Clinical course of acute pancreatitis
The majority of acute pancreatitis cases (around 80%) are mild and self-limiting, and the patients spontaneously recover within 4–5 days after onset. Mild cases have a mortality rate of 1% or less and rarely require intensive care or surgical management.1
However, severe acute pancreatitis develops in 10%–20% of cases and part of the pancreas and surrounding tissue becomes necrotic. Severe cases are associated with local complications such as major organ failure, pancreatic necrosis, pancreatic abscess, and pancreatic pseudocysts and are generally classified into two stages.5 The first stage of severe acute pancreatitis, the period within 2 weeks after the onset of the disease, is characterized by the systemic inflammatory response syndrome (SIRS), and pancreatic necrosis develops in parallel with that within the first 4 days after onset. The second stage begins 2 or 3 weeks after onset with the development of infectious pancreatic complications such as infected pancreatic necrosis (bacterial infection of the pancreatic necrosis) and pancreatic abscess. Infection of pancreatic necrosis is a major prognostic risk factor in severe pancreatitis, and sepsis-related multiple organ failure is the main life-threatening complication with a mortality rate of 20%–50%.
Necrotizing pancreatitis
Clinical Question (CQ) 1. Which procedure will best result in a definite diagnosis of infected pancreatic necrosis?
Computed tomography (CT)-guided or ultrasound (US)-guided fine-needle aspiration for bacteriology should be performed in patients suspected of having infected pancreatic necrosis (Recommendation A)
Acute pancreatitis is classified morphologically into edematous pancreatitis and necrotizing pancreatitis. Edematous pancreatitis accounts for 80%–85% of cases of acute pancreatitis, and most of them are self-limiting and do not require special treatment. The mortality rate for necrotizing pancreatitis, which accounts for 15%–20% of cases, is 30%–40%.6 The mortality rate for infected pancreatic necrosis is high — 40% on average,7 and some studies report rates of more than 70%.8 In contrast, the mortality rate of sterile pancreatic necrosis with no bacterial infection has been reported as being 0%–11%.9,10
Findings suggest that infected pancreatic necrosis presents with a worsening of clinical manifestations and hematological data, a blood culture with positive bacterial results, and a positive result on the endotoxin test of blood and gas in and around the pancreas on a CT scan. However, these findings are merely indirect evidence of infection in general. CT- or US-guided fine-needle aspiration for bacteriology of pancreatic or peripancreatic necrosis has been established as an accurate, safe, and reliable technique for identifying infected necrosis. Its accuracy is high, at 89.4%–100% (Level 2b),11,12 and it is safe if the correct puncture route is chosen and complications such as intestinal injury do not result (Level 2b).
Indications for surgery
CQ2. What is the indication for surgical intervention in necrotizing pancreatitis?
Infected pancreatic necrosis accompanied by signs of sepsis is an indication for surgical intervention (Recommendation B)
It is generally agreed that necrotizing pancreatitis with proven infected necrosis is an indication for surgical intervention (Level 5).1,13,14 It is rarely managed conservatively without surgical intervention.
CQ3. How should sterile pancreatic necrosis be managed?
Patients with sterile pancreatic necrosis should be managed conservatively and undergo surgical intervention only in selected cases, such as those with persistent organ complications or severe clinical deterioration despite maximum intensive care (Recommendation B)
Whether sterile pancreatic necrosis is an indication for surgical intervention remains a matter of controversy. Patients often recover from sterile pancreatic necrosis in response to conservative nonsurgical management (Levels 2c–3b).9,15–17 However, many reports state that failure of acute pancreatitis to improve in response to optimal therapy in an intensive care unit should be an indication for surgical intervention, irrespective of whether the patient has an infection (Levels 2c–3b).18–22 However, these reports have differing views about the length of time that conservative management should be applied before surgical intervention is considered, with the period ranging from 3–5 days to more than 5 weeks. A review23 examining this issue has indicated that although it is difficult to recommend an exact duration, at least 3–4 weeks of conservative management is desirable. However, there are no comparative studies to justify such a conclusion.
Timing of surgery
CQ4. What is the optimal timing for surgical intervention?
Unless there are specific indications, early surgery is not recommended for necrotizing pancreatitis (Recommendation D)
In the past, early surgical intervention was recommended for severe acute pancreatitis, which is often accompanied by major organ failure, beginning in the early stage after onset. However, the high mortality rate of up to 65% casts doubt on the benefits of early surgical intervention.
A retrospective study on the timing of surgery for severe pancreatitis24 revealed a mortality rate in patients treated by delayed surgery of 12%, which is significantly lower than the 39% rate for those who underwent early surgery; thus, surgical intervention should be delayed as long as possible in severe pancreatitis. The only RCT25 comparing early surgery (pancreatic resection/debridement within 72 h of onset) and delayed surgery (the same procedure 11 days after onset) yielded mortality rates of 56% and 27%, respectively. Although the difference between the rates was significant, the trial was terminated because of the very high mortality rate for the patients who underwent early surgery.
The above findings indicate that surgical intervention (necrosectomy) for severe acute pancreatitis patients should be deferred as long as possible (3–4 weeks after the onset).1,3 The reason for this is that the border between normal and necrotic pancreatic tissue becomes more distinct with time, and this may minimize intraoperative hemorrhage and avoid unnecessary removal of normal pancreas. However, a questionnaire survey of physicians specializing in hepatobiliary pancreatic diseases in Europe that asked about surgical intervention for severe pancreatitis showed no consensus regarding the timing of surgery.26
Surgical procedures
CQ5. What is the optimal surgical procedure for infected pancreatic necrosis?
Necrosectomy is recommended as the optimal surgical procedure for infected pancreatic necrosis (Recommendation A)
Surgical procedures employed to treat severe acute pancreatitis in the past included mobilization and drainage of the pancreatic bed and extended pancreatic resection. Drainage of the pancreatic bed was widely used in Japan as a standard surgical procedure in the 1980s through the early 1990s. However, it is no longer used because maximal therapy in an intensive care unit has become the principal procedure for managing severe acute pancreatitis and the advances in imaging modalities have provided objective evidence that the necrotic tissue cannot be removed by a simple drainage procedure.
On the other hand, the extended pancreatic resection that was the major procedure used mainly in European countries from the 1970s through the 1980s has been increasingly avoided in view of the high incidence of postoperative complications, the failure to improve the overall life-saving rate (Level 1b–3b),27,28 and the lowered quality of life in surviving patients because of the development of abnormal glucose tolerance.27
Necrosectomy, or debridement of necrotic tissue, including necrotic pancreatic tissue and peripancreatic fat necrosis, is currently used as the key procedure for necrotizing pancreatitis, and no other surgical procedure produces a better outcome (Level 2c).21,29
Drainage procedures after necrosectomy
CQ6. What is the optimal drainage procedure after necrosectomy?
Simple drainage (Recommendation D) should be avoided as the drainage procedure after necrosectomy, and either continuous closed lavage or open drainage (planned necrosectomy) (Recommendation B) should be performed instead. The choice between these two procedures can be made at the time based on the surgical findings and/or surgeon’s experience
Necrosectomy for necrotizing pancreatitis is designed to remove as much necrotic pancreatic tissue as possible. However, because complete debridement is difficult as a result of hemorrhage and because the outcome depends on how thoroughly the remaining necrotic tissue is removed,29 the simple (conventional) drainage performed in the past should be avoided.
The drainage procedures used to remove the necrotic foci after necrosectomy can be mainly classified as (1) conventional drainage, (2) continuous closed lavage, and (3) open drainage. Conventional drainage is simple drainage through an indwelling drainage tube. Continuous closed lavage consists of continuous local irrigation with 6–8 l/day physiological saline through an indwelling double-lumen tube and is continued until no discharge of necrotic tissue is observed.21 Open drainage is direct drainage through the open wound in the abdominal wall achieved by packing the retroperitoneal space and lesser sac with gauze after necrosectomy, and the same procedure is repeated as scheduled (every 2–3 days) until necrotic tissue is no longer observed.29
Discussion of the comparative advantages of various drainage procedures has continued for more than 20 years, and two reviews based on systematic literature searches have been published. The first review (Level 2a),30 published in 1991, analyzed relevant articles published during the 1980s and revealed that the mortality rate of patients with infected pancreatic necrosis treated by conventional drainage, continuous closed lavage, and open drainage was 42%, 18%, and 21%, respectively, and that the outcome of the conventional drainage group was significantly poorer (P < 0.05). The other review (Level 2a),31 which analyzed articles published in the 1990s, revealed that the mortality rate of the patients with infected pancreatic necrosis treated using the above methods was 23.3%, 10.5%, and 28.3%, respectively. When the analysis was limited to articles dealing with severe cases [an average APACHE II (AP-II) score of 17 or more], the mortality rate was 45.8%, 6.3%, and 23.5%, respectively (Table 1). Both reviews show that patients treated by continuous closed lavage had the best outcome.
However, because of extreme inconsistency between the results of two papers34,45 on continuous closed lavage, both of which were included in the latter systematic review and were reported by the same author at almost the same time, the reliability of the data is highly questionable. In another paper on continuous closed lavage,35 approximately half of the patients underwent repeat laparotomy/debridement 12 or 13 times, and thus the results reported in that paper cannot be considered a pure reflection of the effect of continuous closed lavage.
There is a planned necrosectomy/debridement procedure in which necrosectomy is repeated by temporarily closing the abdominal wound to avoid the excessive invasiveness of open drainage (Level 2c).46 A recent review compared continuous closed lavage, planned necrosectomy (zipper technique), and open drainage.47 The report stated that the mortality rate in necrotizing pancreatitis patients treated by continuous closed lavage, zipper technique, and open drainage was 19%, 24%, and 20.1%, respectively, and that the differences between the groups were not significant. The closed lavage group had a lower incidence of fistula formation (pancreatic fistula and intestinal fistula) and postoperative hemorrhage, but a higher rate of repeat operation, whereas the zipper technique and open drainage were characterized by a higher incidence of fistula formation and postoperative hemorrhage, but a lower rate of repeat operation.
It is difficult to conclude from currently available evidence whether continuous closed lavage or open drainage (or the zipper technique) is better, and in recent years one of these drainage techniques has been chosen freely by surgeons according to the extent of infected necrotic tissue. Continuous closed lavage is chosen when necrotic tissue is localized around the pancreas, and open drainage is recommended if the necrotic area has spread from the root of the mesocolon to the right and/or left paracolic gutter.48
Recently, less-invasive procedures have been preferred. Because the pancreas is a retroperitoneal organ, necrosectomy alone by a retroperitoneal approach is performed with simultaneous local lavage (Level 2c).49,50 The benefits of this procedure are: (1) peritonitis can be prevented because the abdominal cavity is not entered and infecting organisms are not disseminated into the peritoneal cavity, (2) oral intake can be resumed shortly after the operation, (3) the risk of intestinal fistula formation is low, and (4) the incidence of wound infection and abdominal wall incisional hernia is minimized. The disadvantages are associated with the approach being near the head of the pancreas. It is difficult to reach the posterior surface of the duodenum by a retroperitoneal approach from the right side, and an aggressive procedure involves the risk of massive bleeding as a result of damage to the duodenal wall and portal veins.
Moreover, new less-invasive procedures such as percutaneous necrosectomy (Level 2c)51–53 and endoscopic transgastric necrosectomy54 have been tried and yielded favorable results. Proper evaluation of these new management procedures will require the collection of data from additional cases and follow-up examinations.
Pancreatic abscess
CQ7. How should pancreatic abscess be managed? CQ8. What is the indication for surgical drainage in pancreatic abscess?
Surgical or percutaneous drainage should be performed for pancreatic abscess (Recommendation B). If the clinical findings of pancreatic abscess are not improved by percutaneous drainage, surgical drainage should be performed immediately} (Recommendation A)
Pancreatic abscess is an indication for surgical intervention, just as for infected pancreatic necrosis. Pus collection is the main lesion in most pancreatic abscess patients, and it has been recently reported (Level 3b)55,56 that 78%–86% of patients can be managed by percutaneous drainage alone. If a safe puncture route is assured by imaging guidance, this procedure may be the first choice as an aggressive treatment for pancreatic abscess. However, it should be noted that the favorable results reported for this treatment have all been based on retrospective studies, and some of the cases were not pancreatic abscess cases. For example, when severe cases with a Ranson score of 5 or more (Level 2b)57 and cases having multiple abscesses (Level 4)58 were included in the study, the one-stage healing rates of percutaneous drainage declined to 30%–47%. When no improvement in clinical findings is observed after percutaneous drainage, surgical drainage should be performed immediately instead of monitoring the clinical course.59
Pancreatic pseudocysts
CQ9. What are the indications for drainage treatment in pancreatic pseudocysts?
Pancreatic pseudocysts that give rise to symptoms and complications or the diameter of which increases should be treated by drainage (Recommendation A)
Generally agreed indications for drainage treatment of pancreatic pseudocysts include (1) accompaniment by symptoms, such as abdominal pain; (2) complication by infection or bleeding; (3) increase in size during the observation period; (4) a diameter of 6 cm or more; and (5) no tendency to decrease in size during at least 6 weeks of observation. There are no reports opposing indications (1) to (3), but because pseudocysts of 6 cm or larger in diameter may spontaneously resolve after a long follow-up period of 6 weeks or more, (4) and (5), known as “6 cm-6 week criteria,” are not absolute indications for drainage (Levels 3b-4).60,61
CQ10. What is the indication for surgical intervention in pancreatic pseudocysts?
Pancreatic pseudocysts that do not tend to improve in response to percutaneous drainage or endoscopic drainage should be managed surgically (Recommendation A)
The drainage procedures for pancreatic pseudocysts include percutaneous, endoscopic, and surgical drainage (mainly cystoenteric anastomosis). Percutaneous drainage, which is the least invasive and has a cure rate of 80%–100%, is considered a promising alternative to surgical drainage (Levels 2c–3c).62,63 However, some reports have suggested that in a few cases pseudocysts only temporarily resolve after percutaneous drainage (Level 3b),64 whereas other reports have indicated that the complete cure rate as a result of surgical drainage is better than that using other drainage procedures (Level 3b).65,66 One prospective controlled study (Level 2b)57 yielded a one-stage cure rate using percutaneous drainage and surgical drainage of 77% (20/26) and 73% (18/26), respectively, with no significant differences between them.
Because it has been reported that the average duration of catheterization for percutaneous drainage is 16–42 days in cases that respond (Levels 2c–3b),62,63 surgical drainage, such as cystoenteric anastomosis, should be performed if there is no tendency toward improvement even after this duration. When deciding whether the disease is an indication for percutaneous drainage, it is critical to identify the morphology of the pancreatic duct and its relationship to the pancreatic cyst. Percutaneous drainage has been found to be effective in cases in which the pancreatic duct has normal morphology and in which the pancreatic duct is stenosed but does not communicate with the cyst.67 There is a report68 that percutaneous drainage is often ineffective for pancreatic pseudocysts complicated by splenic parenchymal involvement, but that distal pancreatectomy and splenectomy are effective.
Endoscopic management may be indicated in some cases of pancreatic pseudocyst. Transintestinal drainage, such as by transgastric and transduodenal drainage (Level 4), and transpapillary drainage (Level 4),69–71 are indicated, but transgastric drainage should be performed only when compression of the intestinal wall by a cyst can be confirmed endoscopically. It has been suggested that guidance by endoscopic ultrasonography may enhance the safety of drainage procedures (Level 4).72 Transpapillary drainage can be used in cases in which there is communication between the cysts and pancreatic ducts but a transintestinal approach cannot be used. Major complications of endoscopic management include bleeding, infection, and perforation, but there have been no reliable reports comparing effectiveness and safety with that of surgical management.
References
W Uhl A Warshaw C Imrie C Bassi CJ McKay PG Lankish R Carter et al. (2002) ArticleTitleIAP guidelines for the surgical management of acute pancreatitis Pancreatology 2 565–73 10.1159/000071269 Occurrence Handle10.1159/000071269 Occurrence Handle12435871
EL Bradley SuffixIII (2003) ArticleTitleGuiding the reluctant. A primer on guidelines in general and pancreatitis in particular Pancreatology 3 139–43 Occurrence Handle10.1159/000070082 Occurrence Handle12748422
AB Nathens JR Curtis RJ Beale DJ Cook RP Moreno JA Romand et al. (2004) ArticleTitleManagement of the critically ill patient with severe acute pancreatitis Crit Care Med 32 2524–36 10.1097/01.CCM.0000148222.09869.92 Occurrence Handle10.1097/01.CCM.0000148222.09869.92 Occurrence Handle15599161
T Mayumi H Ura S Arata N Kitamura I Kiriyama K Shibuya et al. (2002) ArticleTitleEvidence-based clinical guidelines for acute pancreatitis: proposal J Hepatobiliary Pancreat Surg 9 413–22 10.1007/s005340200051 Occurrence Handle10.1007/s005340200051 Occurrence Handle12483262
J Werner W Uhl W Hartwig T Hackert C Muller O Strobel MW Buchler et al. (2003) ArticleTitleModern phase-specific management of acute pancreatitis Dig Dis 21 38–45 10.1159/000071338 Occurrence Handle10.1159/000071338 Occurrence Handle12837999
I Karimgani KA Porter RE Langevin PA Banks (1992) ArticleTitlePrognostic factors in sterile pancreatic necrosis Gastroenterology 103 1636–40 Occurrence Handle1:STN:280:DyaK3s%2FltFSrtg%3D%3D Occurrence Handle1426885
AL Widdison ND Karanjia (1993) ArticleTitlePancreatic infection complicating acute pancreatitis Br J Surg 80 148–54 Occurrence Handle10.1002/bjs.1800800208 Occurrence Handle1:STN:280:DyaK3s7osVyhtw%3D%3D Occurrence Handle8443638
DB Allardyce (1987) ArticleTitleIncidence of necrotizing pancreatitis and factors related to mortality Am J Surg 154 295–9 10.1016/0002-9610(89)90614-4 Occurrence Handle10.1016/0002-9610(89)90614-4 Occurrence Handle1:STN:280:DyaL2szitlOrsQ%3D%3D Occurrence Handle3631408
EL Bradley SuffixIII K Allen (1991) ArticleTitleA prospective longitudinal study of observation versus surgical intervention in the management of necrotizing pancreatitis Am J Surg 161 19–24 10.1016/0002-9610(91)90355-H Occurrence Handle10.1016/0002-9610(91)90355-H Occurrence Handle1987854
DW Rattner DA Legermate MJ Lee PR Mueller AL Warshaw (1992) ArticleTitleEarly surgical debridement of symptomatic pancreatic necrosis is beneficial irrespective of infection Am J Surg 163 105–9 10.1016/0002-9610(92)90261-O Occurrence Handle10.1016/0002-9610(92)90261-O Occurrence Handle1:STN:280:DyaK387isFKjsg%3D%3D Occurrence Handle1733356
PA Banks SG Gerzof RE Langevin SG Silverman GT Sica MD Hughes (1995) ArticleTitleCT-guided aspiration of suspected pancreatic infection: bacteriology and clinical outcome Int J Pancreatol 18 265–70 Occurrence Handle1:STN:280:DyaK283ktFenug%3D%3D Occurrence Handle8708399
B Rau U Pralle JM Mayer HG Beger (1998) ArticleTitleRole of ultrasonographically guided fine-needle aspiration cytology in the diagnosis of infected pancreatic necrosis Br J Surg 85 179–84 10.1046/j.1365-2168.1998.00707.x Occurrence Handle10.1046/j.1365-2168.1998.00707.x Occurrence Handle1:STN:280:DyaK1c7mt1Cgsw%3D%3D Occurrence Handle9501810
DW McFadden HA Reber (1994) ArticleTitleIndications for surgery in severe acute pancreatitis Int J Pancreatol 15 83–90 Occurrence Handle1:STN:280:DyaK2czltFahuw%3D%3D Occurrence Handle8071574
JHC Ranson (1995) ArticleTitleThe current management of acute pancreatitis Adv Surg 28 93–112 Occurrence Handle1:STN:280:DyaK2M7osFeqtg%3D%3D Occurrence Handle7879692
G Uomo M Visconti G Manes F Calise M Laccetti PG Rabitti (1996) ArticleTitleNonsurgical treatment of acute necrotizing pancreatitis Pancreas 12 142–8 Occurrence Handle10.1097/00006676-199603000-00006 Occurrence Handle1:STN:280:DyaK28zkt12hsQ%3D%3D Occurrence Handle8720660
MW Buchler B Gloor CA Muller H Friess CA Seiler W Uhl (2000) ArticleTitleAcute necrotizing pancreatitis: treatment strategy according to the status of infection Ann Surg 232 619–26 Occurrence Handle10.1097/00000658-200011000-00001 Occurrence Handle1:STN:280:DC%2BD3crhtF2rtA%3D%3D Occurrence Handle11066131
SW Ashley A Perez EA, BS Pierce DC Brooks FD Moore SuffixJr EE Whang et al. (2001) ArticleTitleNecrotizing pancreatitis. Contemporary analysis of 99 consecutive cases Ann Surg 234 572–80 10.1097/00000658-200110000-00016 Occurrence Handle10.1097/00000658-200110000-00016 Occurrence Handle1:STN:280:DC%2BD3MrmslOmug%3D%3D Occurrence Handle11573050
W Hartwig J Werner CA Muller W Uhl MW Buchler (2002) ArticleTitleSurgical management of severe pancreatitis including sterile necrosis J Hepatobiliary Pancreat Surg 9 429–35 Occurrence Handle10.1007/s005340200053 Occurrence Handle12483264
DW Rattner DA Legemate MJ Lee PR Muller AL Warshaw (1992) ArticleTitleEarly surgical debridement of symptomatic pancreatic necrosis is beneficial irrespective of infection Am J Surg 163 105–9 10.1016/0002-9610(92)90261-O Occurrence Handle10.1016/0002-9610(92)90261-O Occurrence Handle1:STN:280:DyaK387isFKjsg%3D%3D Occurrence Handle1733356
C Fernandez-del Castillo DW Rattner MA Makary A Mostafavi D McGrath AL Warshaw (1998) ArticleTitleDebridement and closed packing for the treatment of necrotizing pancreatitis Ann Surg 228 676–84 Occurrence Handle10.1097/00000658-199811000-00007 Occurrence Handle1:STN:280:DyaK1M%2FkvFGmsA%3D%3D Occurrence Handle9833806
HG Beger M Buchler R Bittner S Block T Nevalainen R Roscher (1988) ArticleTitleNecrosectomy and postoperative local lavage in necrotizing pancreatitis Br J Surg 75 207–12 Occurrence Handle10.1002/bjs.1800750306 Occurrence Handle1:STN:280:DyaL1c7msVaktg%3D%3D Occurrence Handle3349326
T Foitzik E Klar HJ Buhr C Herfarth (1995) ArticleTitleImproved survival in acute necrotizing pancreatitis despite limiting the indications for surgical debridement Eur J Surg 161 187–92 Occurrence Handle1:STN:280:DyaK2Mzit1Gktg%3D%3D Occurrence Handle7599297
P Buchler HA Reber (1999) ArticleTitleSurgical approach in patients with acute pancreatitis. Is infected or sterile necrosis an indication — in whom should this be done, when, and why? Gastroenterol Clin North Am 28 661–71 10.1016/S0889-8553(05)70079-0 Occurrence Handle10.1016/S0889-8553(05)70079-0 Occurrence Handle1:STN:280:DyaK1Mvjt1Olsg%3D%3D Occurrence Handle10503142
W Hartwig SM Maksan T Foitzik J Schmidt C Herfarth E Klar (2002) ArticleTitleReduction in mortality with delayed surgical therapy of severe pancreatitis J Gastrointest Surg 6 481–7 10.1016/S1091-255X(02)00008-2 Occurrence Handle10.1016/S1091-255X(02)00008-2 Occurrence Handle12023003
J Mier EL Leon A Castillo F Robledo R Blanco (1997) ArticleTitleEarly versus late necrosectomy in severe necrotizing pancreatitis Am J Surg 173 71–5 10.1016/S0002-9610(96)00425-4 Occurrence Handle10.1016/S0002-9610(96)00425-4 Occurrence Handle1:STN:280:DyaK2s3ivVarug%3D%3D Occurrence Handle9074366
NK King AK Siriwardena (2004) ArticleTitleEuropean survey of surgical strategies for the management of severe acute pancreatitis Am J Gastroenterol 99 719–28 10.1111/j.1572-0241.2004.04111.x Occurrence Handle10.1111/j.1572-0241.2004.04111.x Occurrence Handle15089907
E Kivilaakso M Lempinen A Makelainen P Nikki T Schroder (1984) ArticleTitlePancreatic resection versus peritoneal lavation for acute fulminant pancreatitis. A randomized prospective study Ann Surg 199 426–31 Occurrence Handle10.1097/00000658-198404000-00009 Occurrence Handle1:STN:280:DyaL2c7nslKisA%3D%3D Occurrence Handle6712318
T Schroder V Sainio L Kivisaari P Puolakkainen E Kivilaakso M Lempinen (1991) ArticleTitlePancreatic resection versus peritoneal lavage in acute necrotizing pancreatitis. A prospective randomized trial Ann Surg 214 663–6 Occurrence Handle1:STN:280:DyaK38%2FnsVyntw%3D%3D Occurrence Handle1741645 Occurrence Handle10.1097/00000658-199112000-00004
EL Bradley SuffixIII (1987) ArticleTitleManagement of infected pancreatic necrosis by open drainage Ann Surg 206 542–50 Occurrence Handle10.1097/00000658-198710000-00015 Occurrence Handle3662663
A D’Egidio M Schein (1991) ArticleTitleSurgical strategies in the treatment of pancreatic necrosis and infection Br J Surg 78 133–7 Occurrence Handle10.1002/bjs.1800780204 Occurrence Handle2015459
S Isaji T Kinai T Naganuma Y Kawarada (2000) ArticleTitleSurgical treatment strategy for acute necrotizing pancreatitis (in Japanese) ICU CCU 24 665–72
JA Harris RP Jury J Catto JL Glover (1995) ArticleTitleClosed drainage versus open packing of infected pancreatic necrosis Am Surg 61 612–7 Occurrence Handle1:STN:280:DyaK2MzhsVSltg%3D%3D Occurrence Handle7793743
GB Doglietto D Gui F Pacelli G Brisinda R Bellantone P Crucitti et al. (1994) ArticleTitleOpen versus closed treatment of secondary pancreatic infections. A review of 42 cases Arch Surg 129 689–93 Occurrence Handle1:STN:280:DyaK2c3ps1altg%3D%3D Occurrence Handle8024447
G Farkas J Marton Y Mandi E Szederkenyi A Balogh (1998) ArticleTitleProgress in the management and treatment of infected pancreatic necrosis Scan J Gastroenterol 228 31–7 Occurrence Handle1:STN:280:DyaK1M%2Fot12quw%3D%3D
G Branum J Galloway W Hirchowitz M Fendley J Hunter (1998) ArticleTitlePancreatic necrosis: results of necrosectomy, packing, and ultimate closure over drains Ann Surg 227 870–7 10.1097/00000658-199806000-00010 Occurrence Handle10.1097/00000658-199806000-00010 Occurrence Handle1:STN:280:DyaK1c3pvFKlsQ%3D%3D Occurrence Handle9637550
A Chaudhary P Dhar A Sachdev AK Agarwal (1997) ArticleTitleSurgical management of pancreatic necrosis presenting with locoregional complications Br J Surg 84 965–8 10.1046/j.1365-2168.1997.02748.x Occurrence Handle10.1002/bjs.1800840716 Occurrence Handle1:STN:280:DyaK2szosVCluw%3D%3D Occurrence Handle9240137
S Kriwanek M Gschwantler P Beckerhinn C Armbruster R Roka (1999) ArticleTitleComplications after surgery for necrotizing pancreatitis: risk factors and prognosis Eur J Surg 165 952–7 Occurrence Handle10.1080/110241599750008062 Occurrence Handle1:STN:280:DC%2BD3c%2FjvFalsg%3D%3D Occurrence Handle10574103
EL Bradley SuffixIII (1999) ArticleTitleOperative versus nonoperative therapy in necrotizing pancreatitis Digestion 60 IssueIDSuppl 1 19–21 Occurrence Handle10.1159/000051448 Occurrence Handle10026426
H Van Goor WJ Sluiter RP Bleichrodt (1997) ArticleTitleEarly and long-term results of necrosectomy and planned re-exploration for infected pancreatic necrosis Eur J Surg 163 611–8 Occurrence Handle1:STN:280:DyaK2svkt1eltw%3D%3D Occurrence Handle9298914
AG Margulies HE Akin (1997) ArticleTitleMarsupialization of the pancreas for infected pancreatic necrosis Am Surg 63 261–5 Occurrence Handle1:STN:280:DyaK2s7ovVeisw%3D%3D Occurrence Handle9036896
R Orlando SuffixIII JP Welch CM Akbari GP Bloom WP Macaulay (1993) ArticleTitleTechniques and complications of open packing of infected pancreatic necrosis Surg Gynecol Obstet 177 65–71 Occurrence Handle8322153
R Fugger F Schulz M Rogy F Herbst D Mirza A Fritsch (1991) ArticleTitleOpen approach in pancreatic and infected pancreatic necrosis: laparostomies and preplanned revisions World J Surg 15 516–20 Occurrence Handle10.1007/BF01675650 Occurrence Handle1:STN:280:DyaK3MzmvVGnsw%3D%3D Occurrence Handle1891938
M Schein (1991) ArticleTitlePlanned reoperations and open management in critical intra-abdominal infections: prospective experience in 52 cases World J Surg 15 537–45 10.1007/BF01675658 Occurrence Handle10.1007/BF01675658 Occurrence Handle1:STN:280:DyaK3MzmvVGntw%3D%3D Occurrence Handle1832509
R Stanten CF Frey (1990) ArticleTitleComprehensive management of acute necrotizing pancreatitis and pancreatic abscess Arch Surg 125 1269–74 Occurrence Handle1:STN:280:DyaK3M%2FisVGnuw%3D%3D Occurrence Handle2222168
G Farkas J Marton Y Mandi E Szederkenyi (1996) ArticleTitleSurgical strategy and management of infected pancreatic necrosis Br J Surg 83 930–3 Occurrence Handle10.1002/bjs.1800830714 Occurrence Handle1:STN:280:DyaK28vgvVOqsA%3D%3D Occurrence Handle8813777
JL Garcia-Sabrido JM Tallado NV Christou JR Polo E Valdecantos (1988) ArticleTitleTreatment of severe intra-abdominal sepsis and/or necrotic foci by an “open-abdomen” approach. Zipper and zipper-mesh techniques Arch Surg 123 152–6 Occurrence Handle1:STN:280:DyaL1c7jtlehtw%3D%3D Occurrence Handle3277582
C Bassi G Butturini M Falconi R Salvia I Frigeri P Pederzoli (2003) ArticleTitleOutcome of open necrosectomy in acute pancreatitis Pancreatology 3 128–32 10.1159/000070080 Occurrence Handle10.1159/000070080 Occurrence Handle1:STN:280:DC%2BD3s3islWitg%3D%3D Occurrence Handle12748421
R Kasperk KP Riesener V Schumpelick (1999) ArticleTitleSurgical therapy of severe acute pancreatitis: a flexible approach gives excellent results Hepatogastroenterology 46 467–71 Occurrence Handle1:STN:280:DyaK1M3ksFGhuw%3D%3D Occurrence Handle10228845
EL Van Vyve MS Reynaert BG Lengele JT Pringot JB Otte PJ Kestens (1992) ArticleTitleRetroperitoneal laparostomy: a surgical treatment of pancreatic abscesses after an acute necrotizing pancreatitis Surgery 111 369–75 Occurrence Handle1:STN:280:DyaK383htlGrsA%3D%3D Occurrence Handle1532674
Z Morise K Yamafuji A Asami K Takeshima N Hayashi T Endo et al. (2003) ArticleTitleDirect retroperitoneal open drainage via a long posterior oblique incision for infected necrotizing pancreatitis: report of three cases Surg Today 33 315–8 10.1007/s005950300072 Occurrence Handle10.1007/s005950300072 Occurrence Handle12707833
CR Carter CJ McKay CW Imrie (2000) ArticleTitlePercutaneous necrosectomy and sinus tract endoscopy in the management of infected pancreatic necrosis: an initial experience Ann Surg 232 175–80 Occurrence Handle10.1097/00000658-200008000-00004 Occurrence Handle1:STN:280:DC%2BD3cvgvVGmtw%3D%3D Occurrence Handle10903593
C Connora P Ghaneha M Raratya R Suttona E Rossoa CJ Garveyb et al. (2003) ArticleTitleMinimally invasive retroperitoneal pancreatic necrosectomy Dig Surg 20 270–7 Occurrence Handle10.1159/000071184
VN Pamoukian M Gagner (2001) ArticleTitleLaparoscopic necrosectomy for acute necrotizing pancreatitis J Hepatobiliary Pancreat Surg 8 221–3 10.1007/s005340170020 Occurrence Handle10.1007/s005340170020 Occurrence Handle1:STN:280:DC%2BD3MvgtFahtQ%3D%3D Occurrence Handle11455483
H Seifert T Wehrmann T Schmitt S Zeuzem WF Caspary (2000) ArticleTitleRetroperitoneal endoscopic debridement for infected peripancreatic necrosis Lancet 356 653–5 10.1016/S0140-6736(00)02611-8 Occurrence Handle10.1016/S0140-6736(00)02611-8 Occurrence Handle1:STN:280:DC%2BD3cvjvVyrtw%3D%3D Occurrence Handle10968442
E Van Sonnenberg GR Wittich KS Chon HB D’Agostino G Casola D Easter et al. (1997) ArticleTitlePercutaneous radiologic drainage of pancreatic abscesses Am J Roentgenol 168 979–84 Occurrence Handle1:STN:280:DyaK2s3ktlehsg%3D%3D
NB Baril PW Ralls SM Wren RR Selby R Radin D Parekh et al. (2000) ArticleTitleDoes an infected peripancreatic fluid collection or abscess mandate operation? Ann Surg 231 361–7 10.1097/00000658-200003000-00009 Occurrence Handle10.1097/00000658-200003000-00009 Occurrence Handle1:STN:280:DC%2BD3c7nslWisw%3D%3D Occurrence Handle10714629
EK Lang RM Paolini A Pottmeyer (1991) ArticleTitleThe efficacy of palliative and definitive percutaneous versus surgical drainage of pancreatic abscesses and pseudocysts: a prospective study of 85 patients South Med J 84 55–64 Occurrence Handle1:STN:280:DyaK3M%2Fps1Sjtw%3D%3D Occurrence Handle1702557
MJ Lee DW Rattner DA Legemate S Saini SL Dawson PF Hahn et al. (1992) ArticleTitleAcute complicated pancreatitis: redefining the role of interventional radiology Radiology 183 171–4 Occurrence Handle1:STN:280:DyaK387ps1artQ%3D%3D Occurrence Handle1549667
G Srikanth SS Sikora SS Baijal A Ayyagiri A Kumar R Saxena VK Kapoor (2002) ArticleTitlePancreatic abscess: 10 years experience Aust N Z J Surg 72 881–6 10.1046/j.1445-2197.2002.02584.x Occurrence Handle10.1046/j.1445-2197.2002.02584.x Occurrence Handle1:STN:280:DC%2BD38jit1Gntg%3D%3D
CJ Yeo JA Bastidas A Lynch-Nyhan EK Fishman MJ Zinner JL Cameron (1990) ArticleTitleThe natural history of pancreatic pseudocysts documented by computed tomography Surg Gynecol Obstet 170 411–7 Occurrence Handle1:STN:280:DyaK3c3itlWqsA%3D%3D Occurrence Handle2326721
GJ Vitas MG Sarr (1992) ArticleTitleSelected management of pancreatic pseudocysts: operative versus expectant management Surgery 111 123–30 Occurrence Handle1:STN:280:DyaK387ktF2jtg%3D%3D Occurrence Handle1736380
A D’Egidio M Schein (1992) ArticleTitlePercutaneous drainage of pancreatic pseudocysts: a prospective study World J Surg 16 141–5 10.1007/BF02067130 Occurrence Handle10.1007/BF02067130 Occurrence Handle1290254
DB Adams MC Anderson (1992) ArticleTitlePercutaneous catheter drainage compared with internal drainage in the management of pancreatic pseudocyst Ann Surg 215 571–6 Occurrence Handle10.1097/00000658-199206000-00003 Occurrence Handle1:STN:280:DyaK38zjslCluw%3D%3D Occurrence Handle1632678
E Criado AA De Stefano TM Weiner PF Jaques (1992) ArticleTitleLong-term results of percutaneous catheter drainage of pancreatic pseudocysts Surg Gynecol Obstet 175 293–8 Occurrence Handle1:STN:280:DyaK3s%2FjtFWksQ%3D%3D Occurrence Handle1411884
R Heider AA Meyer JA Galanko KE Behrns (1999) ArticleTitlePercutaneous drainage of pancreatic pseudocysts is associated with a higher failure rate than surgical treatment in unselected patients Ann Surg 229 781–7 10.1097/00000658-199906000-00004 Occurrence Handle10.1097/00000658-199906000-00004 Occurrence Handle1:STN:280:DyaK1M3ptVGmuw%3D%3D Occurrence Handle10363891
P Soliani C Franzini S Ziegler P Del Rio P Dell’Abate D Piccolo et al. (2004) ArticleTitlePancreatic pseudocysts following acute pancreatitis: risk factors influencing therapeutic outcomes J Pancreas 5 338–47
WH Nealon E Walser (2002) ArticleTitleMain pancreatic ductal anatomy can direct choice of modality for treating pancreatic pseudocysts (surgery versus percutaneous drainage) Ann Surg 235 751–8 10.1097/00000658-200206000-00001 Occurrence Handle10.1097/00000658-200206000-00001 Occurrence Handle12035030
R Heider KE Behrns (2001) ArticleTitlePancreatic pseudocysts complicated by splenic parenchymal involvement: results of operative and percutaneous management Pancreas 23 20–5 10.1097/00006676-200107000-00003 Occurrence Handle10.1097/00006676-200107000-00003 Occurrence Handle1:STN:280:DC%2BD38%2FitVCktA%3D%3D Occurrence Handle11451143
KF Binmoeller H Seifert A Walter N Soehendra (1995) ArticleTitleTranspapillary and transmural drainage of pancreatic pseudocysts Gastrointest Endosc 42 219–24 10.1016/S0016-5107(95)70095-1 Occurrence Handle10.1016/S0016-5107(95)70095-1 Occurrence Handle1:STN:280:DyaK28%2Fotl2qtA%3D%3D Occurrence Handle7498686
M Barthet J Sahel C Bodiou-Bertei JP Bernard (1995) ArticleTitleEndoscopic transpapillary drainage of pancreatic pseudocysts Gastrointest Endosc 42 208–13 10.1016/S0016-5107(95)70093-5 Occurrence Handle10.1016/S0016-5107(95)70093-5 Occurrence Handle1:STN:280:DyaK28%2Fotl2qtg%3D%3D Occurrence Handle7498684
GC Vitale JC Lawhon GM Larson DJ Harrell DN Reed SuffixJr S MacLeod (1999) ArticleTitleEndoscopic drainage of the pancreatic pseudocyst Surgery 126 616–21 Occurrence Handle1:STN:280:DyaK1MvkvFaitA%3D%3D Occurrence Handle10520906
H Seifert C Dietrich T Schmitt W Caspary T Wehrmann (2000) ArticleTitleEndoscopic ultrasound-guided one-step transmural drainage of cystic abdominal lesions with a large-channel echo endoscope Endoscopy 32 255–9 10.1055/s-2000-93 Occurrence Handle10.1055/s-2000-93 Occurrence Handle1:STN:280:DC%2BD3c7otFehsg%3D%3D Occurrence Handle10718392
Author information
Authors and Affiliations
About this article
Cite this article
Isaji, S., Takada, T., Kawarada, Y. et al. JPN Guidelines for the management of acute pancreatitis:surgical management. J Hepatobiliary Pancreat Surg 13, 48–55 (2006). https://doi.org/10.1007/s00534-005-1051-7
Issue Date:
DOI: https://doi.org/10.1007/s00534-005-1051-7