Proposal of diagnostic criteria for IgG4-related thyroid disease

DOI Web Site PubMed 参考文献36件 オープンアクセス
  • Takeshima Ken
    First Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan
  • Li Yaqiong
    Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong, 250021, China
  • Kakudo Kennichi
    Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi 594-0073, Japan
  • Hirokawa Mitsuyoshi
    Department of Diagnostic Pathology, Kuma Hospital, Kobe 650-0011, Japan
  • Nishihara Eijun
    Department of Internal Medicine, Kuma Hospital, Kobe 650-0011, Japan
  • Shimatsu Akira
    Advanced Medical Care Center, Kusatsu General Hospital, Kusatsu 525-8585, Japan Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan
  • Takahashi Yutaka
    Department of Diabetes and Endocrinology, Nara Medical University Hospital, Nara 634-8522, Japan
  • Akamizu Takashi
    First Department of Internal Medicine, Wakayama Medical University, Wakayama 641-8509, Japan Department of Internal Medicine, Kuma Hospital, Kobe 650-0011, Japan

この論文をさがす

抄録

<p>Patients with IgG4-related disease (IgG4-RD) are diagnosed in Japan by comprehensive or organ-specific diagnostic criteria. To date, organ-specific criteria have been established for several organs, but not for the thyroid. We attempted to establish diagnostic criteria for IgG4-related thyroid disease (IgG4-RTD) based on IgG4-RD research by The Research Program on Intractable Diseases from the Ministry of Health, Labour and Welfare of Japan. These criteria have been publicly reported to members of both the Japan Endocrine Society and the Japan Thyroid Association. Thyroid diseases associated with IgG4 include Hashimoto’s thyroiditis, Graves’ disease and Riedel’s thyroiditis. As a comprehensive definition that includes both systematic and organ-specific forms, we use the broad term ‘IgG4-related thyroid disease’. Diagnostic criteria for IgG4-RTD comprise the following five items: I) enlargement of the thyroid, II) hypoechoic lesions in the thyroid by ultrasonography, III) elevated serum IgG4 levels, IV) histopathological findings in the thyroid lesion (IgG4+ plasma cells >20/HPF and IgG4+/IgG+ plasma cell ratio >30%) and V) involvement of other organs. “Definitive” diagnosis of IgG4-RTD is made when I, II, III and IV are all fulfilled, while “probable” diagnosis of IgG4-RTD is when I, II, and IV or V are fulfilled. Patients who fulfill I, II and III criteria are considered as “possible” IgG4-RTD. We believe that the proposed diagnostic criteria contribute to more accurate diagnosis of IgG4-RTD as well as exclusion of mimicry. Furthermore, they may lead to better understanding of the clinical implications and underlying pathogenesis of IgG4-RTD.</p>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 68 (1), 1-6, 2021

    一般社団法人 日本内分泌学会

参考文献 (36)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報

問題の指摘

ページトップへ